![]() ![]() Accumulating data indicate that insights gained from the link between inflammation and atherosclerosis can yield predictive and prognostic information of considerable clinical utility. Compelling evidence for the importance of inflammation and atherosclerosis at both the basic and clinical level has evolved in parallel. Although it was formerly considered a bland lipid storage disease, substantial advances in basic and experimental science have illuminated the role of inflammation and the underlying cellular and molecular mechanisms that contribute to atherogenesis. ![]() Over the last dozen years, appreciation of the role of inflammation in atherosclerosis has burgeoned. These new insights into inflammation in atherosclerosis not only increase our understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance. In the case of lipid lowering with statins, this anti-inflammatory effect does not appear to correlate with reduction in low-density lipoprotein levels. Moreover, certain treatments that reduce coronary risk also limit inflammation. ![]() In addition, low-grade chronic inflammation, as indicated by levels of the inflammatory marker C-reactive protein, prospectively defines risk of atherosclerotic complications, thus adding to prognostic information provided by traditional risk factors. Elevation in markers of inflammation predicts outcomes of patients with acute coronary syndromes, independently of myocardial damage. Clinical studies have shown that this emerging biology of inflammation in atherosclerosis applies directly to human patients. These new findings provide important links between risk factors and the mechanisms of atherogenesis. Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the thrombotic complications of atherosclerosis. Customer Service and Ordering InformationĪtherosclerosis, formerly considered a bland lipid storage disease, actually involves an ongoing inflammatory response.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB). ![]()
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